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Basic Informations
- The name Sir2 comes from the yeast gene 'Silent mating-type Information Regulation 2', the gene responsible for cellular regulation un yeast.
- Chemically a class of proteins that posess either mono-ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity.
- a family of signaling proteins involved in metabolic regulation.
- Possessing a highly conserved structure throughout all kingdoms of life.
http://m.genesdev.cshlp.org/content/14/9/1021.full
Genes Dev | Mobile
Sir2 links chromatin silencing, metabolism, and aging Leonard Guarente1 Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139 USA Aging is manifested by a progressive decline in vitality over time leading to dea
m.genesdev.cshlp.org
Sir2 Metabolism
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